House of the Dragon yang turut serta bermain di dalamnya ada Matt Smith, Olivia Cooke, Emma D’Arcy, Rhys Ifans, Steve Toussaint, Eve Best, Sonoya Mizuno, Graham McTavish, Jefferson Hall, David Horovitch, Matthew Needham, Bill Patterson, Gavin Spokes, Wil Johnson, John Macmillan, Savannah Steyn, Theo Nate.
Di Season 2 ini juga ada pemain baru seperti Gayle Rankin, Russell Beale, Freddie Fox, Abubakar Salim.
